Caliber Sciences / Info

FAQ

What is this site, and who is it for?

This is a private, citation-based reference to injectable peptide compounds: what each one is, what evidence exists behind it, and how it is dosed and reconstituted where a citable figure exists.

What does an evidence tier mean, and why does every compound have one?

Every compound entry is assigned exactly one of five tiers, from strongest to weakest: Approved drug, human RCT evidence; Human trials, not approved for this use; Early human data only; Animal and in-vitro only; and Anecdotal, no controlled data. The tier is stated first, before mechanism or dosing, because two compounds can be reconstituted with the same bacteriostatic water and drawn into the same syringe while resting on entirely different evidence. Reading only one fact about a compound should mean reading its tier.

Why do some entries say no citable dose exists? Isn't that a gap in the research?

It is a finding, not a gap. Where the literature reviewed for this reference contains no citable human dose, half-life, or post-reconstitution stability figure, the entry states that plainly instead of filling the space with a plausible-sounding number. That happened 81 times across this reference. A stated absence means the figure was looked for and not found in the published sources reviewed, which is a different and more useful thing to know than silence would be.

What is the difference between an FDA-approved indication and community practice?

An approved indication is a use the FDA, or an equivalent regulator, has reviewed trial data for and authorized on the compound's own label, for example semaglutide's approval for glycemic control in type 2 diabetes. Community practice is a use, dose, or route reported by people who use a compound outside that regulatory record, never studied in the literature this reference cites. The two are never blended into one figure: where an entry carries both, for example BPC-157's single published 4 mg intra-articular dose alongside a community-reported subcutaneous range, the community figure is labeled as unsourced and shown separately, specifically so it is never mistaken for a clinical or regulatory finding.

How do I read a reconstitution worked example?

A worked example starts from the vial strength and diluent volume actually used, for example a 5 mg vial mixed with 2 mL of bacteriostatic water, to get a concentration in mg per mL. A standard U-100 insulin syringe delivers 100 units per mL, so one unit equals 0.01 mL; dividing a target dose by the concentration gives the volume to draw, and multiplying that volume by 100 gives the syringe reading in units. Every worked example on this site is drawn from either an FDA label instruction or an explicitly labeled vendor or commercial convention, never a recommendation, and the ratio varies by vendor: it must be confirmed against the specific vial on hand before drawing anything, never assumed from the example.

Is anything on this site medical advice?

No. This is a research and educational reference, not medical advice. Nothing on this site is a recommendation to use any compound. If you are making a decision about your own health, that decision belongs to you and a qualified clinician, not to this reference.